Arsenal moved back into the Premier League's top five with a route win over Brighton at the Emirates Stadium.
Nacho Monreal opened the scoring with his first ever goal at the stadium, pouncing on Aaron Ramsey's rebounded effort to slot home in the first half.
Both teams hit the post and Seas Kolasinac had a header cleared off the line before Alex Iwobi settled matters.
Elsewhere, Everton's poor formed continued as they were beaten 1-0 at home to Burnley, while Liverpool missed the chance to move above Arsenal and Chelsea after drawing away to Newcastle in the weekend's final match.
EPL Table | Premier League 2017-18 season table
| Pos | Team | P | W | D | L | GD | Pts |
| 1 | Man City | 7 | 6 | 1 | 0 | 20 | 19 |
| 2 | Man United | 7 | 6 | 1 | 0 | 19 | 19 |
| 3 | Tottenham | 7 | 4 | 2 | 1 | 9 | 14 |
| 4 | Chelsea | 7 | 4 | 1 | 2 | 6 | 13 |
| 5 | Arsenal | 7 | 4 | 1 | 2 | 3 | 13 |
| 6 | Burnley | 7 | 3 | 3 | 1 | 2 | 12 |
| 7 | Liverpool | 7 | 3 | 3 | 1 | 1 | 12 |
| 8 | Watford | 7 | 3 | 3 | 1 | -1 | 12 |
| 9 | Newcastle | 7 | 3 | 1 | 3 | 1 | 10 |
| 10 | West Brom | 7 | 2 | 3 | 2 | -2 | 9 |
| 11 | Huddersfield | 7 | 2 | 3 | 2 | -2 | 9 |
| 12 | Southampton | 7 | 2 | 2 | 3 | -2 | 8 |
| 13 | Stoke | 7 | 2 | 2 | 3 | -4 | 8 |
| 14 | Brighton | 7 | 2 | 1 | 4 | -4 | 7 |
| 15 | West Ham | 7 | 2 | 1 | 4 | -6 | 7 |
| 16 | Everton | 7 | 2 | 1 | 4 | -8 | 7 |
| 17 | Leicester | 7 | 1 | 2 | 4 | -3 | 5 |
| 18 | Swansea | 7 | 1 | 2 | 4 | -5 | 5 |
| 19 | Bournemouth | 7 | 1 | 1 | 5 | -7 | 4 |
| 20 | Crystal Palace | 7 | 0 | 0 | 7 | -17 | 0 |
Alvaro Morata suffered a hamstring injury as Pep Guardiola's City outclasses Antonio Conte's Blues, with Kevin De Bruyne's stunning second-half goal sealing three points in west London.
In Pictures | Huddersfield vs Tottenham | 30/09/2017
That defeat saw Chelsea miss the chance to leapfrog rivals Tottenham who had moved up to third in the table with their comfortable 4-0 victory away at Huddersfield. Harry Kane score twice, with Ben Davies and Moussa Sissoko adding the fourth.
Manchester United briefly went top on goal difference as they cruised to victory over Crystal Palace at Old Trafford earlier in the day.
Marouane Fellaini scored twice after Juan Mata's opener, and Romelu Lukaku capped the victory with a fourth late on as Palace failed to score for a seventh straight game.
In Pictures | Chelsea vs Man City | 30/09/2017
Across the capital, West Ham substitute Diafra Sakho hit a late winner as the Hammers beat Swansea at te London Stadium.
Elsewhere, former Southampton star Peter Crouch scored the winner as Stoke beat Saints at the Bet365 Stadium as Watford's last-gasp goal ensured they shared the spoils at West Brom.
Leicester and Bournemouth played out a goalless draw on the south coast.
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