Prime Minister Gordon Brown will attempt to fight back after a torrid summer with a Cabinet meeting at the Olympic Park.
The Government's top team will gather for the first time since parliament went into recess, and carry out a series of visits in east London.
But the event comes amid more evidence that recent criticism of the campaign in Afghanistan and the handling of the Lockerbie bomber row has inflicted significant political damage.
A YouGov survey for the Sun newspaper suggested that the Conservatives were heading for a 96-seat Commons majority at the next general election.
David Cameron's Tories have a 42% share of the vote, with Labour trailing on 28% and the Liberal Democrats on 17%.
The poll, the first of the party conference season, also found voters believed Mr Cameron would make a better prime minister than Mr Brown by a factor of two to one.
Mr Brown will now try to rally his Cabinet to convince voters that its strategy of spending during the recession has had a marked effect on the economy's recovery.
The Cabinet meeting comes days before G20 finance ministers gather in London to join Chancellor Alistair Darling for talks on the world economy.
The Prime Minister will also attempt to finally draw a line under the Lockerbie row, which on Wednesday led him to deny "double dealing" over the bomber's release from a Scottish prison.
The meeting is the latest in a series of Cabinet "away days". Mr Brown's Cabinet meeting in Birmingham last year was thought to be the first such event to be held outside London since 1921.
